Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial: Study protocol for a randomized controlled trial

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dc.contributor.authorArenaza, Lide
dc.contributor.authorMedrano, María
dc.contributor.authorAmasene, María
dc.contributor.authorRodríguez-Vigil, Beatriz
dc.contributor.authorDíez, Ignacio
dc.contributor.authorGraña, Manuel
dc.contributor.authorTobalina, Ignacio
dc.contributor.authorMaiz, Edurne
dc.contributor.authorArteche, Edurne
dc.contributor.authorLarrarte, Eider
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorDavis, Catherine L.
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorMargareto, Javier
dc.contributor.authorLabayen, Idoia
dc.contributor.institutionGenerales
dc.contributor.institutionGenética
dc.date.issued2017-08-10
dc.descriptionPublisher Copyright: © 2017 The Author(s).
dc.description.abstractBackground: The global pandemic of obesity has led to an increased risk for prediabetes and type-2 diabetes (T2D). The aims of the current project are: (1) to evaluate the effect of a 22-week family based intervention program, including supervised exercise, on insulin resistance syndrome (IRS) risk in children with a high risk of developing T2D and (2) to identify the profile of microRNA in circulating exosomes and in peripheral blood mononuclear cells in children with a high risk of developing T2D and its response to a multidisciplinary intervention program including exercise. Methods: A total of 84 children, aged 8-12 years, with a high risk of T2D will be included and randomly assigned to control (N = 42) or intervention (N = 42) groups. The control group will receive a family based lifestyle education and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week, 90 min per session including warm-up, moderate to vigorous aerobic activities, and strength exercises). The following measurements will be evaluated at baseline prior to randomization and after the intervention: fasting insulin, glucose and hemoglobin A1c; body composition (dual-energy X-ray absorptiometry); ectopic fat (magnetic resonance imaging); microRNA expression in circulating exosomes and in peripheral blood mononuclear cells (MiSeq; Illumina); cardiorespiratory fitness (cardiopulmonary exercise testing); dietary habits and physical activity (accelerometry). Discussion: Prevention and identification of children with a high risk of developing T2D could help to improve their cardiovascular health and to reduce the comorbidities associated with obesity.en
dc.description.statusPeer reviewed
dc.format.extent799211
dc.identifier.citationArenaza , L , Medrano , M , Amasene , M , Rodríguez-Vigil , B , Díez , I , Graña , M , Tobalina , I , Maiz , E , Arteche , E , Larrarte , E , Huybrechts , I , Davis , C L , Ruiz , J R , Ortega , F B , Margareto , J & Labayen , I 2017 , ' Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial : Study protocol for a randomized controlled trial ' , Trials , vol. 18 , no. 1 , 372 . https://doi.org/10.1186/s13063-017-2117-y
dc.identifier.doi10.1186/s13063-017-2117-y
dc.identifier.issn1745-6215
dc.identifier.otherresearchoutputwizard: 11556/456
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85027098526&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofTrials
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsType-2 diabetes
dc.subject.keywordsChildren
dc.subject.keywordsExercise
dc.subject.keywordsFamily based lifestyle intervention program
dc.subject.keywordsmiRNA
dc.subject.keywordsEctopic fat
dc.subject.keywordsType-2 diabetes
dc.subject.keywordsChildren
dc.subject.keywordsExercise
dc.subject.keywordsFamily based lifestyle intervention program
dc.subject.keywordsmiRNA
dc.subject.keywordsEctopic fat
dc.subject.keywordsMedicine (miscellaneous)
dc.subject.keywordsPharmacology (medical)
dc.subject.keywordsSDG 3 - Good Health and Well-being
dc.subject.keywordsFunding Info
dc.subject.keywordsThe Spanish Ministry of Industry and_x000D_ Competitiveness (DEP2016-78377-R), by “Fondos Estructurales de la Unión_x000D_ Europea (FEDER), Una manera de hacer Europa.” and by the University of the_x000D_ Basque Country (GIU14/21). This work was also supported by grants from_x000D_ Spanish Ministry of Economy and Competitiveness (RYC-2010-05957; RYC-_x000D_ 2011-09011), Spanish Ministry of Education, Culture and Sports (FPU14/_x000D_ 03329) and by the Education, Linguistic Policy and Culture Department of_x000D_ the Government of the Basque Country (PRE_2016_1_0057).
dc.subject.keywordsThe Spanish Ministry of Industry and_x000D_ Competitiveness (DEP2016-78377-R), by “Fondos Estructurales de la Unión_x000D_ Europea (FEDER), Una manera de hacer Europa.” and by the University of the_x000D_ Basque Country (GIU14/21). This work was also supported by grants from_x000D_ Spanish Ministry of Economy and Competitiveness (RYC-2010-05957; RYC-_x000D_ 2011-09011), Spanish Ministry of Education, Culture and Sports (FPU14/_x000D_ 03329) and by the Education, Linguistic Policy and Culture Department of_x000D_ the Government of the Basque Country (PRE_2016_1_0057).
dc.titlePrevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial: Study protocol for a randomized controlled trialen
dc.typejournal article
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