Brain–Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Stroke

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dc.contributor.authorCaria, Andrea
dc.contributor.authorda Rocha, Josué Luiz Dalboni
dc.contributor.authorGallitto, Giuseppe
dc.contributor.authorBirbaumer, Niels
dc.contributor.authorSitaram, Ranganatha
dc.contributor.authorMurguialday, Ander Ramos
dc.contributor.institutionMedical Technologies
dc.date.accessioned2024-07-24T12:09:56Z
dc.date.available2024-07-24T12:09:56Z
dc.date.issued2020-04-01
dc.descriptionPublisher Copyright: © 2019, The American Society for Experimental NeuroTherapeutics, Inc.
dc.description.abstractBrain–machine interfaces (BMI) permit bypass motor system disruption by coupling contingent neuroelectric signals related to motor activity with prosthetic devices that enhance afferent and proprioceptive feedback to the somatosensory cortex. In this study, we investigated neural plasticity in the motor network of severely impaired chronic stroke patients after an EEG-BMI-based treatment reinforcing sensorimotor contingency of ipsilesional motor commands. Our structural connectivity analysis revealed decreased fractional anisotropy in the splenium and body of the corpus callosum, and in the contralesional hemisphere in the posterior limb of the internal capsule, the posterior thalamic radiation, and the superior corona radiata. Functional connectivity analysis showed decreased negative interhemispheric coupling between contralesional and ipsilesional sensorimotor regions, and decreased positive intrahemispheric coupling among contralesional sensorimotor regions. These findings indicate that BMI reinforcing ipsilesional brain activity and enhancing proprioceptive function of the affected hand elicits reorganization of contralesional and ipsilesional somatosensory and motor-assemblies as well as afferent and efferent connection–related motor circuits that support the partial re-establishment of the original neurophysiology of the motor system even in severe chronic stroke.en
dc.description.sponsorshipThis work was supported by the German Federal Ministry of Education and Research (BMBF, Förderzeichen 01GQ0831); Deutsche Forschungsgemeinschaft (DFG) Koselleck (BI 195/58-1); European Research Council (ERC 227632); European Union FP7-ICT-2009-231724 - HUMOR: Human Behavioral Modeling for Enhancing Learning by Optimizing Human-Robot Interaction, FP7-ICT-2009-247935 – BETTER: BNCI-driven Robotic Physical Therapies in Stroke Rehabilitation of Gait Disorders; Italian Ministry of Health GR-2009-159190; BW-Stiftung (ROB-1); Werner Reichardt Centre for Integrative Neuroscience (CIN). The authors would like to thank Balint Varkuti, Leonhard Läer, Pavel Terekhin, Nicolas Lindau, and Bjorn Schiffler for their support.
dc.description.statusPeer reviewed
dc.format.extent16
dc.identifier.citationCaria , A , da Rocha , J L D , Gallitto , G , Birbaumer , N , Sitaram , R & Murguialday , A R 2020 , ' Brain–Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Stroke ' , Neurotherapeutics , vol. 17 , no. 2 , pp. 635-650 . https://doi.org/10.1007/s13311-019-00816-2
dc.identifier.doi10.1007/s13311-019-00816-2
dc.identifier.issn1933-7213
dc.identifier.urihttps://hdl.handle.net/11556/4026
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85076210751&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofNeurotherapeutics
dc.relation.projectIDBW-Stiftung
dc.relation.projectIDFP7-ICT-2009-247935
dc.relation.projectIDConsejo Interuniversitario Nacional, CIN
dc.relation.projectIDEuropean Commission, EC, FP7-ICT-2009-231724
dc.relation.projectIDEuropean Research Council, ERC, ERC 227632
dc.relation.projectIDDeutsche Forschungsgemeinschaft, DFG, BI 195/58-1
dc.relation.projectIDWerner Reichardt Centre for Neuroscience, CIN
dc.relation.projectIDBundesministerium für Bildung und Forschung, BMBF, 01GQ0831
dc.relation.projectIDMinistero della Salute, GR-2009-159190
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsBrain–machine interface
dc.subject.keywordsDTI
dc.subject.keywordsfunctional connectivity
dc.subject.keywordsmotor recovery
dc.subject.keywordsstroke
dc.subject.keywordsPharmacology
dc.subject.keywordsNeurology (clinical)
dc.subject.keywordsPharmacology (medical)
dc.subject.keywordsSDG 3 - Good Health and Well-being
dc.titleBrain–Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Strokeen
dc.typejournal article
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