Brain oscillatory activity as a biomarker of motor recovery in chronic stroke

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dc.contributor.authorRay, Andreas M.
dc.contributor.authorFigueiredo, Thiago D. C.
dc.contributor.authorLópez‐Larraz, Eduardo
dc.contributor.authorBirbaumer, Niels
dc.contributor.authorRamos‐Murguialday, Ander
dc.contributor.authorLópez-Larraz, Eduardo
dc.contributor.authorRamos-Murguialday, Ander
dc.contributor.institutionMedical Technologies
dc.date.issued2020-04-01
dc.descriptionPublisher Copyright: © 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.
dc.description.abstractIn the present work, we investigated the relationship of oscillatory sensorimotor brain activity to motor recovery. The neurophysiological data of 30 chronic stroke patients with severe upper‐limb paralysis are the basis of the observational study presented here. These patients underwent an intervention including movement training based on combined brain–machine interfaces and physiotherapy of several weeks recorded in a double‐blinded randomized clinical trial. We analyzed the alpha oscillations over the motor cortex of 22 of these patients employing multilevel linear predictive modeling. We identified a significant correlation between the evolution of the alpha desynchronization during rehabilitative intervention and clinical improvement. Moreover, we observed that the initial alpha desynchronization conditions its modulation during intervention: Patients showing a strong alpha desynchronization at the beginning of the training improved if they increased their alpha desynchronization. Patients showing a small alpha desynchronization at initial training stages improved if they decreased it further on both hemispheres. In all patients, a progressive shift of desynchronization toward the ipsilesional hemisphere correlates significantly with clinical improvement regardless of lesion location. The results indicate that initial alpha desynchronization might be key for stratification of patients undergoing BMI interventions and that its interhemispheric balance plays an important role in motor recovery.en
dc.description.statusPeer reviewed
dc.format.extent13
dc.format.extent1322530
dc.identifier.citationRay , A M , Figueiredo , T D C , López‐Larraz , E , Birbaumer , N , Ramos‐Murguialday , A , López-Larraz , E & Ramos-Murguialday , A 2020 , ' Brain oscillatory activity as a biomarker of motor recovery in chronic stroke ' , Human Brain Mapping , vol. 41 , no. 5 , pp. 1296-1308 . https://doi.org/10.1002/hbm.24876
dc.identifier.doi10.1002/hbm.24876
dc.identifier.issn1065-9471
dc.identifier.otherresearchoutputwizard: 11556/836
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85075758793&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofHuman Brain Mapping
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsSensorimotor brain activity
dc.subject.keywordsMotor recovery
dc.subject.keywordsSevere upper-limb paralysis
dc.subject.keywordsSensorimotor brain activity
dc.subject.keywordsMotor recovery
dc.subject.keywordsSevere upper-limb paralysis
dc.subject.keywordsEEG
dc.subject.keywordsmotor control
dc.subject.keywordsneuronal plasticity
dc.subject.keywordsrehabilitation
dc.subject.keywordsstroke
dc.subject.keywordsAnatomy
dc.subject.keywordsRadiological and Ultrasound Technology
dc.subject.keywordsRadiology, Nuclear Medicine and Imaging
dc.subject.keywordsNeurology
dc.subject.keywordsNeurology (clinical)
dc.subject.keywordsSDG 3 - Good Health and Well-being
dc.subject.keywordsFunding Info
dc.subject.keywordsBundesministerium für Bildung und Forschung, Grant/Award Numbers: 13GW0053, 16SV7754; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst, Grant/Award Number: 91563355
dc.subject.keywordsBundesministerium für Bildung und Forschung, Grant/Award Numbers: 13GW0053, 16SV7754; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst, Grant/Award Number: 91563355
dc.titleBrain oscillatory activity as a biomarker of motor recovery in chronic strokeen
dc.typejournal article
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