Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review: A systematic review

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dc.contributor.authorOses, Maddi
dc.contributor.authorMargareto Sanchez, Javier
dc.contributor.authorPortillo, Maria P.
dc.contributor.authorAguilera, Concepción María
dc.contributor.authorLabayen, Idoia
dc.contributor.institutionTecnalia Research & Innovation
dc.contributor.institutionGenética
dc.date.issued2019-12
dc.descriptionPublisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractEarly detection of obesity and its associated comorbidities in children needs priority for the development of effective therapeutic intervention. Circulating miRNAs (microRNAs) have been proposed as biomarkers for obesity and its comorbidities; therefore, we conducted a systematic review to summarize results of studies that have quantified the profile of miRNAs in children and adolescents with obesity and/or associated disorders. Nine studies aiming to examine differences in miRNA expression levels between children with normal weight and obesity or between obese children with or without cardiometabolic diseases were included in this review. We identified four miRNAs overexpressed in obesity (miR-222, miR-142–3, miR-140-5p, and miR-143) and two miRNAs (miR-122 and miR-34a) overexpressed in children with obesity and nonalcoholic fatty liver disease (NAFLD) and/or insulin resistance. In conclusion, circulating miRNAs are promising diagnostic biomarkers of obesity-associated diseases such as NAFLD and type 2 diabetes already in childhood. However, more studies in children, using massive search technology and with larger sample sizes, are required to draw any firm conclusions.en
dc.description.statusPeer reviewed
dc.format.extent1
dc.format.extent476406
dc.identifier.citationOses , M , Margareto Sanchez , J , Portillo , M P , Aguilera , C M & Labayen , I 2019 , ' Circulating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review : A systematic review ' , Nutrients , vol. 11 , no. 12 , 2890 , pp. 2890 . https://doi.org/10.3390/nu11122890
dc.identifier.doi10.3390/nu11122890
dc.identifier.issn2072-6643
dc.identifier.otherresearchoutputwizard: 11556/839
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85075620012&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofNutrients
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsmiRNAs
dc.subject.keywordsChildhood obesity
dc.subject.keywordsBiomarkers
dc.subject.keywordsmiRNAs
dc.subject.keywordsChildhood obesity
dc.subject.keywordsBiomarkers
dc.subject.keywordsFood Science
dc.subject.keywordsNutrition and Dietetics
dc.subject.keywordsSDG 3 - Good Health and Well-being
dc.subject.keywordsFunding Info
dc.subject.keywordsThis research was funded by the Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R) and by the European Regional Development Fund (ERDF), M.O. is supported by a grant from the Spanish Ministry of Economy and Competitiveness, grant number; BES-2017-080770 and the APC was funded by additional support from the University of Granada, UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme, and Excellence Actions Programe. C.M.A. and I.L.G. are part of the “URG Plan propio de Investigación 2016” and the “Excellence actions: Unit of Excellence on Exercise and Health (UCEES), University of Granada.
dc.subject.keywordsThis research was funded by the Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R) and by the European Regional Development Fund (ERDF), M.O. is supported by a grant from the Spanish Ministry of Economy and Competitiveness, grant number; BES-2017-080770 and the APC was funded by additional support from the University of Granada, UGR Research and Knowledge Transfer Fund (PPIT) 2016, Excellence Actions Programme, and Excellence Actions Programe. C.M.A. and I.L.G. are part of the “URG Plan propio de Investigación 2016” and the “Excellence actions: Unit of Excellence on Exercise and Health (UCEES), University of Granada.
dc.titleCirculating miRNAs as Biomarkers of Obesity and Obesity-Associated Comorbidities in Children and Adolescents: A Systematic Review: A systematic reviewen
dc.typejournal article
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