A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study: Long-term effects in the exerdiet-hta study

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dc.contributor.authorCorres, Pablo
dc.contributor.authorFryer, Simon M.
dc.contributor.authorAguirre-Betolaza, Aitor Martínez
dc.contributor.authorGorostegi-Anduaga, Ilargi
dc.contributor.authorArratibel-Imaz, Iñaki
dc.contributor.authorPérez-Asenjo, Javier
dc.contributor.authorFrancisco-Terreros, Silvia
dc.contributor.authorSaracho, Ramón
dc.contributor.authorMaldonado-Martín, Sara
dc.contributor.institutionTecnalia Research & Innovation
dc.date.issued2020-04-02
dc.descriptionPublisher Copyright: © 2020 by the authors.
dc.description.abstractMetabolically unhealthy obesity (MUO) is a regular state in people with primary hypertension (HTN), obesity, and who are physically inactive. To achieve and maintain a metabolically healthy overweight/obese (MHO) state should be a main treatment goal. The aims of the study were (1) to determine differences in metabolic profiles of overweight/obese, physically inactive individuals with HTN following a 16-week (POST) supervised aerobic exercise training (SupExT) intervention with an attentional control (AC) group, and (2) to determine whether the changes observed were maintained following six months (6 M) of unsupervised time. Participants (n = 219) were randomly assigned into AC or SupExT groups. All participants underwent a hypocaloric diet. At POST, all participants received diet and physical activity advice for the following 6 M, with no supervision. All measurements were assessed pre-intervention (PRE), POST, and after 6 M. From PRE to POST, MUO participants became MHO with improved (p < 0.05) total cholesterol (TC, ∆ = −12.1 mg/dL), alanine aminotransferase (∆ = −8.3 U/L), glucose (∆ = −5.5 mg/dL), C-reactive protein (∆ = −1.4 mg/dL), systolic blood pressure (SBP), and cardiorespiratory fitness (CRF) compared to unhealthy optimal cut-off values. However, after 6 M, TC, glucose, and SBP returned to unhealthy values (p < 0.05). In a non-physically active population with obesity and HTN, a 16-week SupExT and diet intervention significantly improves cardiometabolic profile from MUO to MHO. However, after 6 M of no supervision, participants returned to MUO. The findings of this study highlight the need for regular, systematic, and supervised diet and exercise programs to avoid subsequent declines in cardiometabolic health.en
dc.description.statusPeer reviewed
dc.format.extent1
dc.format.extent714609
dc.identifier.citationCorres , P , Fryer , S M , Aguirre-Betolaza , A M , Gorostegi-Anduaga , I , Arratibel-Imaz , I , Pérez-Asenjo , J , Francisco-Terreros , S , Saracho , R & Maldonado-Martín , S 2020 , ' A Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study : Long-term effects in the exerdiet-hta study ' , International Journal of Environmental Research and Public Health , vol. 17 , no. 8 , 2830 , pp. 2830 . https://doi.org/10.3390/ijerph17082830
dc.identifier.doi10.3390/ijerph17082830
dc.identifier.issn1661-7827
dc.identifier.otherresearchoutputwizard: 11556/917
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85084002157&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofInternational Journal of Environmental Research and Public Health
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsObesity
dc.subject.keywordsHypertension
dc.subject.keywordsInactivity
dc.subject.keywordsSupervised exercise
dc.subject.keywordsObesity
dc.subject.keywordsHypertension
dc.subject.keywordsInactivity
dc.subject.keywordsSupervised exercise
dc.subject.keywordsPollution
dc.subject.keywordsPublic Health, Environmental and Occupational Health
dc.subject.keywordsHealth, Toxicology and Mutagenesis
dc.subject.keywordsSDG 3 - Good Health and Well-being
dc.subject.keywordsFunding Info
dc.subject.keywordsP.C., A.M.A.-B., and I.G.-A. were supported by the Basque Government with predoctoral grants. This study was supported by the University of the Basque Country (EHU14/08, PPGA18/15).
dc.subject.keywordsP.C., A.M.A.-B., and I.G.-A. were supported by the Basque Government with predoctoral grants. This study was supported by the University of the Basque Country (EHU14/08, PPGA18/15).
dc.titleA Metabolically Healthy Profile Is a Transient Stage When Exercise and Diet Are Not Supervised: Long-Term Effects in the EXERDIET-HTA Study: Long-term effects in the exerdiet-hta studyen
dc.typejournal article
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