Brain-computer interface in paralysis

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dc.contributor.authorBirbaumer, Niels
dc.contributor.authorMurguialday, Ander Ramos
dc.contributor.authorCohen, Leonardo
dc.contributor.institutionMedical Technologies
dc.date.accessioned2024-07-24T12:06:11Z
dc.date.available2024-07-24T12:06:11Z
dc.date.issued2008-12
dc.description.abstractPurpose of review: Communication with patients suffering from locked-in syndrome and other forms of paralysis is an unsolved challenge. Movement restoration for patients with chronic stroke or other brain damage also remains a therapeutic problem and available treatments do not offer significant improvements. This review considers recent research in brain-computer interfaces (BCIs) as promising solutions to these challenges. Recent findings: Experimentation with nonhuman primates suggests that intentional goal directed movements of the upper limbs can be reconstructed and transmitted to external manipulandum or robotic devices controlled from a relatively small number of microelectrodes implanted into movement-relevant brain areas after some training, opening the door for the development of BCI or brain-machine interfaces in humans. Although noninvasive BCIs using electroencephalographic recordings or event-related-brain-potentials in healthy individuals and patients with amyotrophic lateral sclerosis or stroke can transmit up to 80 bits/min of information, the use of BCIs - invasive or noninvasive - in severely or totally paralyzed patients has met some unforeseen difficulties. Summary: Invasive and noninvasive BCIs using recordings from nerve cells, large neuronal pools such as electrocorticogram and electroencephalography, or blood flow based measures such as functional magnetic resonance imaging and near-infrared spectroscopy show potential for communication in locked-in syndrome and movement restoration in chronic stroke, but controlled phase III clinical trials with larger populations of severely disturbed patients are urgently needed.en
dc.description.statusPeer reviewed
dc.format.extent5
dc.identifier.citationBirbaumer , N , Murguialday , A R & Cohen , L 2008 , ' Brain-computer interface in paralysis ' , Current Opinion in Neurology , vol. 21 , no. 6 , pp. 634-638 . https://doi.org/10.1097/WCO.0b013e328315ee2d
dc.identifier.doi10.1097/WCO.0b013e328315ee2d
dc.identifier.issn1350-7540
dc.identifier.urihttps://hdl.handle.net/11556/3635
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=56749127998&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofCurrent Opinion in Neurology
dc.relation.projectIDNational Institute of Neurological Disorders and Stroke, NINDS, Z01NS002978-Z01NS003030
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject.keywordsAmyotrophic lateral sclerosis
dc.subject.keywordsMovement restoration
dc.subject.keywordsStroke
dc.subject.keywordsNeurology
dc.subject.keywordsNeurology (clinical)
dc.subject.keywordsSDG 3 - Good Health and Well-being
dc.titleBrain-computer interface in paralysisen
dc.typejournal article
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