Plasma polymerized silylated ciprofloxacin as an antibiotic coating

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dc.contributor.authorBraceras, Inigo
dc.contributor.authorAzpiroz, Patxi
dc.contributor.authorBriz, Nerea
dc.contributor.authorFratila, Raluca M.
dc.contributor.authorOyarbide, Joseba
dc.contributor.authorIpiñazar, Enrique
dc.contributor.authorÚlvarez, Noelia
dc.contributor.authorAtorrasagasti, Garbiñe
dc.contributor.authorAizpurua, Jesus M.
dc.contributor.institutionINGENIERÍA DE SUPERFICIES
dc.contributor.institutionTECNOLOGÍAS DE HIDRÓGENO
dc.contributor.institutionSG
dc.contributor.institutionVALORIZACIÓN DE RESIDUOS
dc.contributor.institutionBiomateriales
dc.date.accessioned2024-07-24T11:59:41Z
dc.date.available2024-07-24T11:59:41Z
dc.date.issued2011-07-22
dc.description.abstractLocally applied antibiotics under temporally controlled release present many advantages over systemic clinical treatments, e.g. efficiency and side effects. This can be achieved by a coating on top of the medical device, in which the antibiotic is stored. This study presents the use of plasma polymerization to produce such a coating using N,O-bis-tert- butyldimethylsilylated ciprofloxacin (silylciprofloxacin) as a precursor. Once exposed to physiological media, the outer layers of the coating release the antibiotic by a hydrolysis reaction. Thus, the plasma process parameters can control the speed of liberation through the coating polymerization. Besides, this study shows that the release products present antibiotic activity against a number of bacteria: E. coli, P. aeruginosa, and S. aureus. Ciprofloxacin release dynamics can be controlled by coating plasma polymerization parameters, allowing local controlled delivery of active antibiotic in physiologic conditions, and thus higher efficiency and lower side effects.en
dc.description.statusPeer reviewed
dc.format.extent8
dc.identifier.citationBraceras , I , Azpiroz , P , Briz , N , Fratila , R M , Oyarbide , J , Ipiñazar , E , Úlvarez , N , Atorrasagasti , G & Aizpurua , J M 2011 , ' Plasma polymerized silylated ciprofloxacin as an antibiotic coating ' , Plasma Processes and Polymers , vol. 8 , no. 7 , pp. 599-606 . https://doi.org/10.1002/ppap.201000160
dc.identifier.doi10.1002/ppap.201000160
dc.identifier.issn1612-8850
dc.identifier.urihttps://hdl.handle.net/11556/2969
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=79960221322&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofPlasma Processes and Polymers
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject.keywordsantibacterial coatings
dc.subject.keywordsdrug release
dc.subject.keywordshydrolysis
dc.subject.keywordsinfection
dc.subject.keywordsplasma polymerization
dc.subject.keywordsCondensed Matter Physics
dc.subject.keywordsPolymers and Plastics
dc.titlePlasma polymerized silylated ciprofloxacin as an antibiotic coatingen
dc.typejournal article
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