DNA copy number variation and gene expression analyses reveal the implication of specific oncogenes and genes in GBM

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dc.contributor.authorMargareto, Javier
dc.contributor.authorLeis, Olatz
dc.contributor.authorLarrarte, Eider
dc.contributor.authorPomposo, Iñigo C.
dc.contributor.authorGaribi, Jesús María
dc.contributor.authorLafuente, Jose Vicenté
dc.contributor.institutionGenética
dc.contributor.institutionGenerales
dc.date.accessioned2024-07-24T12:08:09Z
dc.date.available2024-07-24T12:08:09Z
dc.date.issued2009-06
dc.description.abstractTo understand the pathogenesis of glioblastoma multiforme (GBM) we used high-resolution comparative genomic hybridization arrays and gene expression microarrays to identify DNA copy number alterations and gene expression changes in comparable sets of GBM samples. Gains were detected at chromosomes 1, 2, 7, 9, 12, 19, and 20 and losses at 6, 9, and 10. Gene expression analyses identified specific genes overexpressed in GBM mapping at amplified chromosomal regions. Among these genes we found genes involved in angiogenesis, extracellular matrix remodeling and several oncogenes. DNA copy number analysis along with gene expression profiles provides a powerful strategy to understand tumor progression and identification of genes involved in GBM pathogenesis.en
dc.description.sponsorshipOlatz Leis is supported by the Health Department of the Basque Country Government. This work was financially supported by grants 9/212.327-15887 (University of the Basque Country), SAIOTEK (Dpt. Industry of the Basque Country); G03/114 Instituto de Salud Carlos III (Spanish Health Ministry) Fundación Mutua Madrileña and IT/460/07 (Basque Government).
dc.description.statusPeer reviewed
dc.format.extent8
dc.identifier.citationMargareto , J , Leis , O , Larrarte , E , Pomposo , I C , Garibi , J M & Lafuente , J V 2009 , ' DNA copy number variation and gene expression analyses reveal the implication of specific oncogenes and genes in GBM ' , Cancer Investigation , vol. 27 , no. 5 , pp. 541-548 . https://doi.org/10.1080/07357900802563044
dc.identifier.doi10.1080/07357900802563044
dc.identifier.issn0735-7907
dc.identifier.urihttps://hdl.handle.net/11556/3839
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=67449106767&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofCancer Investigation
dc.relation.projectIDHealth Department of the Basque Country Government
dc.relation.projectIDEuskal Herriko Unibertsitatea, EHU
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject.keywordsCGH array
dc.subject.keywordsCopy number gains
dc.subject.keywordsGene expression
dc.subject.keywordsGlioblastoma
dc.subject.keywordsOncology
dc.subject.keywordsCancer Research
dc.titleDNA copy number variation and gene expression analyses reveal the implication of specific oncogenes and genes in GBMen
dc.typejournal article
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