Novel bioactive scaffolds incorporating nanogels as potential drug eluting devices

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dc.contributor.authorSaez-Martinez, Virginia
dc.contributor.authorOlalde, Beatriz
dc.contributor.authorJuan, Maria Jesus
dc.contributor.authorJurado, Maria Jesus
dc.contributor.authorGaragorri, Nerea
dc.contributor.authorObieta, Isabel
dc.contributor.institutionBiomateriales
dc.contributor.institutionMATERIALES PARA CONDICIONES EXTREMAS
dc.contributor.institutionTecnalia Research & Innovation
dc.date.accessioned2024-07-24T12:13:11Z
dc.date.available2024-07-24T12:13:11Z
dc.date.issued2010-04
dc.description.abstractBig advances are being achieved in the design of new implantable devices with enhanced properties. For example, synthetic porous three-dimensional structures can mimic the architecture of the tissues, and serve as templates for cell seeding. In addition, polymeric nanoparticles are able to provide a programmable and sustained local delivery of different types of biomolecules. In this study novel alternative scaffolds with controlled bioactive properties and architectures are presented. Two complementary approaches are described. Firstly, scaffolds with nanogels as active controlled release devices incorporated inside the three-dimensional structure are obtained using the thermally induced phase separation (TIPS) method. Secondly, a novel coating method using the spraying technique to load these nanometric crosslinked hydrogels on the surface of two-dimensional (2D) and three-dimensional (3D) biodegradable scaffolds is described. The scanning electron microscopy (SEM) images show the distribution of the nanogels on the surface of different substrates and also inside the porous structure of poly-α-hydroxy ester derivative foams. Both of them are compared in terms of manufacturability, dispersion and other processing variables.en
dc.description.statusPeer reviewed
dc.format.extent7
dc.identifier.citationSaez-Martinez , V , Olalde , B , Juan , M J , Jurado , M J , Garagorri , N & Obieta , I 2010 , ' Novel bioactive scaffolds incorporating nanogels as potential drug eluting devices ' , Journal of Nanoscience and Nanotechnology , vol. 10 , no. 4 , pp. 2826-2832 . https://doi.org/10.1166/jnn.2010.1448
dc.identifier.doi10.1166/jnn.2010.1448
dc.identifier.issn1533-4880
dc.identifier.urihttps://hdl.handle.net/11556/4347
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=77952767075&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of Nanoscience and Nanotechnology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject.keywordsControlled release
dc.subject.keywordsNanogels
dc.subject.keywordsNanoparticles
dc.subject.keywordsScaffolds
dc.subject.keywordsSpray-Coating
dc.subject.keywordsTIPS
dc.subject.keywordsBioengineering
dc.subject.keywordsGeneral Chemistry
dc.subject.keywordsBiomedical Engineering
dc.subject.keywordsGeneral Materials Science
dc.subject.keywordsCondensed Matter Physics
dc.titleNovel bioactive scaffolds incorporating nanogels as potential drug eluting devicesen
dc.typejournal article
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