Melanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomography

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dc.contributor.authorSaratxaga, Cristina L.
dc.contributor.authorAsumendi, Aintzane
dc.contributor.authorGardeazabal, Jesús
dc.contributor.authorIzu, Rosa M.
dc.contributor.authorSanchez, Ana
dc.contributor.authorCancho-Galan, Goikoana
dc.contributor.authorMorales, Celia
dc.contributor.authorLage, Sergio
dc.contributor.authorBoyano, Maria D.
dc.contributor.authorConde, Olga M.
dc.contributor.authorGarrote, Estibaliz
dc.contributor.institutionVISUAL
dc.contributor.institutionQuantum
dc.date.accessioned2024-07-24T12:05:27Z
dc.date.available2024-07-24T12:05:27Z
dc.date.issued2023-03
dc.descriptionPublisher Copyright: © 2023 by the authors.
dc.description.abstractBackground: Melanoma incidence has continued to rise in the latest decades, and the forecast is not optimistic. Non-invasive diagnostic imaging techniques such as optical coherence tomography (OCT) are largely studied; however, there is still no agreement on its use for the diagnosis of melanoma. For dermatologists, the differentiation of non-invasive (junctional nevus, compound nevus, intradermal nevus, and melanoma in-situ) versus invasive (superficial spreading melanoma and nodular melanoma) lesions is the key issue in their daily routine. Methods: This work performs a comparative analysis of OCT images using haematoxylin–eosin (HE) and anatomopathological features identified by a pathologist. Then, optical and textural properties are extracted from OCT images with the aim to identify subtle features that could potentially maximize the usefulness of the imaging technique in the identification of the lesion’s potential invasiveness. Results: Preliminary features reveal differences discriminating melanoma in-situ from superficial spreading melanoma and also between melanoma and nevus subtypes that pose a promising baseline for further research. Conclusions: Answering the final goal of diagnosing non-invasive versus invasive lesions with OCT does not seem feasible in the short term, but the obtained results demonstrate a step forward to achieve this.en
dc.description.sponsorshipThis work has been funded by the Department of Economic Development, Sustainability and the Environment of the Basque Government (Spain) ELKARTEK projects ONKOTOOLS with grant numbers KK-2020/00069, the Spanish Ministry of Science and Education CERVERA project AI4ES with grant numbers CER-20211030, and by the ECSEL JU European project ASTONISH with the grant number 692470, UC Industrial Doctorate DI14.
dc.description.statusPeer reviewed
dc.identifier.citationSaratxaga , C L , Asumendi , A , Gardeazabal , J , Izu , R M , Sanchez , A , Cancho-Galan , G , Morales , C , Lage , S , Boyano , M D , Conde , O M & Garrote , E 2023 , ' Melanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomography ' , Life , vol. 13 , no. 3 , 625 . https://doi.org/10.3390/life13030625
dc.identifier.doi10.3390/life13030625
dc.identifier.issn2075-1729
dc.identifier.urihttps://hdl.handle.net/11556/3558
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85152081130&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofLife
dc.relation.projectIDDepartment of Economic Development
dc.relation.projectIDSpanish Ministry of Science and Education, CER-20211030
dc.relation.projectIDEusko Jaurlaritza, KK-2020/00069
dc.relation.projectIDUniversidad de Cantabria, UC
dc.relation.projectIDElectronic Components and Systems for European Leadership, ECSEL, 692470
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subject.keywordsCADx
dc.subject.keywordsHE
dc.subject.keywordshistopathology
dc.subject.keywordsmelanoma
dc.subject.keywordsOCT
dc.subject.keywordsoptical biopsy
dc.subject.keywordsoptical properties
dc.subject.keywordsskin cancer
dc.subject.keywordstextural properties
dc.subject.keywordsEcology, Evolution, Behavior and Systematics
dc.subject.keywordsGeneral Biochemistry,Genetics and Molecular Biology
dc.subject.keywordsSpace and Planetary Science
dc.subject.keywordsPaleontology
dc.subject.keywordsSDG 3 - Good Health and Well-being
dc.titleMelanoma and Nevi Subtype Histopathological Characterization with Optical Coherence Tomographyen
dc.typejournal article
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