Fabrication of ultrahigh-molecular-weight polyethylene porous implant for bone application

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dc.contributor.authorOlalde, Beatriz
dc.contributor.authorAyerdi-Izquierdo, Ana
dc.contributor.authorFernández, Rubén
dc.contributor.authorGarcía-Urkia, Nerea
dc.contributor.authorAtorrasagasti, Garbiñe
dc.contributor.authorBijelic, Goran
dc.contributor.institutionBiomateriales
dc.contributor.institutionMercado
dc.date.accessioned2024-07-24T12:14:22Z
dc.date.available2024-07-24T12:14:22Z
dc.date.issued2020-09-01
dc.descriptionPublisher Copyright: © 2020 Walter de Gruyter GmbH, Berlin/Boston 2020.
dc.description.abstractPorous implants play a crucial role in allowing ingrowth of host connective tissue and thereby help in keeping the implant in its place. With the aim of mimicking the microstructure of natural extracellular matrix, ultrahigh-molecular-weight polyethylene (UHMWPE) porous samples with a desirable pore size distribution were developed by combining thermally induced phase separation and salt leaching techniques. The porous UHMWPE samples consisted of a nanofibrous UHMWPE matrix with a fibre diameter smaller than 500 nm, highly interconnected, with a controllable pore diameter from nanoscale to 300 μm. Moreover, a porous UHMWPE sample was also developed as a continuous and homogeneous coating onto the UHMWPE dense sample. The dense/porous UHMWPE sample supported human foetal osteoblast 1.19 cell line proliferation and differentiation, indicating the potential of porous UHMWPE with a desirable pore size distribution for bone application. An osseointegration model in the sheep revealed substantial bone formation within the pore layer at 12 weeks via SEM evaluation. Ingrown bone was more closely opposed to the pore wall when compared to the dense UHMWPE control. These results indicate that dense/porous UHMWPE could provide improved osseointegration while maintaining the structural integrity necessary for load-bearing orthopaedic application.en
dc.description.sponsorshipEMAITEK program: Basque Government. Basque Government. Department of Technology, Innovation and Competitiveness.
dc.description.statusPeer reviewed
dc.format.extent8
dc.identifier.citationOlalde , B , Ayerdi-Izquierdo , A , Fernández , R , García-Urkia , N , Atorrasagasti , G & Bijelic , G 2020 , ' Fabrication of ultrahigh-molecular-weight polyethylene porous implant for bone application ' , Journal of Polymer Engineering , vol. 40 , no. 8 , pp. 685-692 . https://doi.org/10.1515/polyeng-2019-0386
dc.identifier.doi10.1515/polyeng-2019-0386
dc.identifier.issn0334-6447
dc.identifier.urihttps://hdl.handle.net/11556/4467
dc.identifier.urlhttp://www.scopus.com/inward/record.url?scp=85093652949&partnerID=8YFLogxK
dc.language.isoeng
dc.relation.ispartofJournal of Polymer Engineering
dc.relation.projectIDDepartment of Technology, Innovation and Competitiveness
dc.relation.projectIDEusko Jaurlaritza
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subject.keywordsBone application
dc.subject.keywordsPorous implant
dc.subject.keywordsUHMWPE
dc.subject.keywordsGeneral Chemical Engineering
dc.subject.keywordsPolymers and Plastics
dc.subject.keywordsMaterials Chemistry
dc.titleFabrication of ultrahigh-molecular-weight polyethylene porous implant for bone applicationen
dc.typejournal article
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