Browsing by Keyword "Scaffolds"
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Item Novel bioactive scaffolds incorporating nanogels as potential drug eluting devices(2010-04) Saez-Martinez, Virginia; Olalde, Beatriz; Juan, Maria Jesus; Jurado, Maria Jesus; Garagorri, Nerea; Obieta, Isabel; Biomateriales; MATERIALES PARA CONDICIONES EXTREMAS; Tecnalia Research & InnovationBig advances are being achieved in the design of new implantable devices with enhanced properties. For example, synthetic porous three-dimensional structures can mimic the architecture of the tissues, and serve as templates for cell seeding. In addition, polymeric nanoparticles are able to provide a programmable and sustained local delivery of different types of biomolecules. In this study novel alternative scaffolds with controlled bioactive properties and architectures are presented. Two complementary approaches are described. Firstly, scaffolds with nanogels as active controlled release devices incorporated inside the three-dimensional structure are obtained using the thermally induced phase separation (TIPS) method. Secondly, a novel coating method using the spraying technique to load these nanometric crosslinked hydrogels on the surface of two-dimensional (2D) and three-dimensional (3D) biodegradable scaffolds is described. The scanning electron microscopy (SEM) images show the distribution of the nanogels on the surface of different substrates and also inside the porous structure of poly-α-hydroxy ester derivative foams. Both of them are compared in terms of manufacturability, dispersion and other processing variables.Item Sprayed microgels onto 2D and 3D scaffolds as drug eluting coatings(2008) Juan, M. J.; Olalde, B.; Jurado, M. J.; Mattioli, S.; Bilbao, L.; Saez-Martinez, V.; MATERIALES PARA CONDICIONES EXTREMAS; Biomateriales; Tecnalia Research & Innovation; PRINTEXBig advances are being achieved in the design of new implantable devices. Coated scaffolds capable of releasing bioactive agents for inhibiting totally or partially the inflammatory response of the surrounding tissues, are now being regarded as potential useful systems. Polymeric nanoparticles are known to be able to provide a programmable and sustained local drug delivery [1-3]. In addition, biodegradable and biocompatible scaffolds having a highly open porous structure and good mechanical strength are needed to provide an optimal microenvironment for cell proliferation, migration, and differentiation, and guidance for cellular in-growth from host tissue [4]. This study describes preliminary results on a novel coating method using spraying techniques for coating micro-nanometric crosslinked hydrogels on 3D biodegradable scaffolds.