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Item Application of standardization for the design and construction of carbon nanotube-based product pilot lines in compliance with EU regulation on machinery(2019-10-17) López de Ipiña, Jesús M; Florez, Sonia; Seddon, Richard; Chapartegui, Maialen; Hernan, Angel; Insunza, Mario; Vavouliotis, Antonios; Koutsoukis, Gregorios; Latko-Durałek, Paulina; Durałek, Paweł; Perez, Pilar; Gutierrez-Cañas, Cristina; Tecnalia Research & Innovation; SMART_MON; POLIMEROSThe "PLATFORM" manufacturing ecosystem for pilot production of pre-commercial CNT-based nano-enabled products, consists of three pilot lines (PPLs) for the manufacture of buckypapers, doped prepregs and doped veils. The PPLs have been constructed with the ultimate goal to commercialize these products in the European market in 2020/2022.This goal requires having the PPLs in compliance with the applicable product safety regulation by that date (CE marking). The main EU regulation for new machinery (as the PPLs) is the Directive 2006/42/EC on Machinery (MD). This Directive sets out the general mandatory Essential Health and Safety Requirements (EHSRs) related to the design and construction of machinery, while particular technical specifications for fulfilling them are provided in European harmonized standards. Application of harmonized standards is voluntary but confers a presumption of conformity with the EHSRs they cover. The PPLs are unique machines for own use and must comply with the MD before they are put into service, in 2020/2022. But the MD does not provide specific EHSRs for nanosafety and no harmonized standards are available in this field for the safe design of the PPLs. In this context, this paper shows the standardization strategy followed by the project PLATFORM (GA 646307) to design the PPLs in compliance with the EHSR referred to the risks to health resulting from hazardous substances emitted by machinery (MD, Annex I, EHSR 1.5.13). In the absence of nanosafety harmonized standards to satisfy the aforementioned EHSR, the design and design verification of the PPLs were carried out through A & B - type harmonized standards (e.g. EN ISO 12100, EN ISO 14123-1/2), and other European and international standards.Item Association of lifestyle and early risk obesity variables with the BMI for age categories in Greek, Spanish, and Brazilian schools. POSTER DISCUSSION(Wiley-Blackwell, 2020) Torrego, M.; Cortés Martínez, A.; Del Rey Mejías, A.; Arredondo, E.; Seara, G.; Praça Brasil, C.; Bezerra, I.; Magalh, D.; Reis, Dos; Rodrigues Ferreira, J.; De Vasconcelos, J.; Fontenelle Catrib, A.; Mendes Melo, N.; Rocha, C.; Webert, E.; Costa, L.; Melo, R.; Bastida, Leire; et alChildhood obesity is a multifactorial disease conse- quence of an interaction among a complex set of factors that are related to the environment, genetics, and ecological effects such as the family, community, and school. Interventions tailored to high risk determinants at an early age can prevent or limit the excess weight gain.Item Environmental effects of the application of iron nanoparticles for site remediation(Pan Standford Publishing Pte. Ltd., 2018) Cagigal, Ekain; Ocejo, Marta; Gallego, Jose Luis R.; Pelaez, Ana I.; Rodriguez-Valdes, EduardoAs long as the injection of nanoparticles (mainly nanozerovalent iron, nZVI) has become a common technology for soil and groundwater remediation, a concern has simultaneously grown regarding the side effects and potential impact on the ecosystems, as occurring with other engineered nanometric scale materials. Based on precautionary principle, the technology is still pending approval by regulators in several countries until uncertainties regarding risk analysis are clarified,Item Neurodegeneration trajectory in pediatric and adult/late DM1: A follow‐up MRI study across a decade(Wiley-Blackwell, 2020-10) Labayru, Garazi; Jimenez‐Marin, Antonio; Fernández, Esther; Villanua, Jorge; Zulaica, Miren; Cortes, Jesus M.; Díez, Ibai; Sepulcre, Jorge; López de Munain, Adolfo; Sistiaga, AndoneObjective: To characterize the progression of brain structural abnormalities in adults with pediatric and adult/late onset DM1, as well as to examine the potential predictive markers of such progression. Methods: 21 DM1 patients (pediatric onset: N = 9; adult/late onset: N = 12) and 18 healthy controls (HC) were assessed longitudinally over 9.17 years through brain MRI. Additionally, patients underwent neuropsychological, genetic, and muscular impairment assessment. Inter-group comparisons of total and voxel-level regional brain volume were conducted through Voxel Based Morphometry (VBM); cross-sectionally and longitudinally, analyzing the associations between brain changes and demographic, clinical, and cognitive outcomes. Results: The percentage of GM loss did not significantly differ in any of the groups compared with HC and when assessed independently, adult/late DM1 patients and their HC group suffered a significant loss in WM volume. Regional VBM analyses revealed subcortical GM damage in both DM1 groups, evolving to frontal regions in the pediatric onset patients. Muscular impairment and the outcomes of certain neuropsychological tests were significantly associated with follow-up GM damage, while visuoconstruction, attention, and executive function tests showed sensitivity to WM degeneration over time. Interpretation: Distinct patterns of brain atrophy and its progression over time in pediatric and adult/late onset DM1 patients are suggested. Results indicate a possible neurodevelopmental origin of the brain abnormalities in DM1, along with the possible existence of an additional neurodegenerative process. Fronto-subcortical networks appear to be involved in the disease progression at young adulthood in pediatric onset DM1 patients. The involvement of a multimodal integration network in DM1 is discussed.