Browsing by Keyword "Genetics"
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Item Medical needs related to the endoscopic technology and colonoscopy for colorectal cancer diagnosis(2021-12) Ortega-Morán, Juan Francisco; Azpeitia, Águeda; Sánchez-Peralta, Luisa F.; Bote-Curiel, Luis; Pagador, Blas; Cabezón, Virginia; Saratxaga, Cristina L.; Sánchez-Margallo, Francisco M.; VISUALBackground. The high incidence and mortality rate of colorectal cancer require new technologies to improve its early diagnosis. This study aims at extracting the medical needs related to the endoscopic technology and the colonoscopy procedure currently used for colorectal cancer diagnosis, essential for designing these demanded technologies. Methods. Semi-structured interviews and an online survey were used. Results. Six endoscopists were interviewed and 103 were surveyed, obtaining the demanded needs that can be divided into: a) clinical needs, for better polyp detection and classification (especially flat polyps), location, size, margins and penetration depth; b) computer-aided diagnosis (CAD) system needs, for additional visual information supporting polyp characterization and diagnosis; and c) operational/physical needs, related to limitations of image quality, colon lighting, flexibility of the endoscope tip, and even poor bowel preparation.Item Waste-derived volatile fatty acids as carbon source for added-value fermentation approaches(2021-05-01) Chalima, Angelina; de Castro, Laura Fernandez; Burgstaller, Lukas; Sampaio, Paula; Carolas, Ana Lúcia; Gildemyn, Sylvia; Velghe, Filip; Ferreira, Bruno Sommer; Pais, Celia; Neureiter, Markus; Dietrich, Thomas; Topakas, Evangelos; De Castro, Laura Fernandez; Tecnalia Research & Innovation; Alimentación SostenibleThe establishment of a sustainable circular bioeconomy requires the effective material recycling from biomass and biowaste beyond composting/fertilizer or anaerobic digestion/bioenergy. Recently, volatile fatty acids attracted much attention due to their potential application as carbon source for the microbial production of high added-value products. Their low-cost production from different types of wastes through dark fermentation is a key aspect, which will potentially lead to the sustainable production of fuels, materials or chemicals, while diminishing the waste volume. This article reviews the utilization of a volatile fatty acid platform for the microbial production of polyhydroxyalkanoates, single cell oil and omega-3 fatty acids, giving emphasis on the fermentation challenges for the efficient implementation of the bioprocess and how they were addressed. These challenges were addressed through a research project funded by the European Commission under the Horizon 2020 programme entitled ‘VOLATILE—Biowaste derived volatile fatty acid platform for biopolymers, bioactive compounds and chemical building blocks’.