Browsing by Keyword "Children"
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Item The effect of a multidisciplinary intervention program on hepatic adiposity in overweight-obese children: Protocol of the EFIGRO study: Protocol of the EFIGRO study(2015-11-01) Medrano, M.; Maiz, E.; Maldonado-Martin, Sara; Arenaza, L.; Rodríguez-Vigil, B.; Ortega, F.B.; Ruiz, J.R.; Larrarte, E.; Diez-López, I.; Sarasúa-Miranda, A.; Tobalina, I.; Barrenechea, L.; Pérez-Asenjo, J.; Kannengiesser, S.; Manhães-Savio, A.; Echaniz, O.; Labayen, I.; GeneralesBackground: Non-alcoholic fatty liver disease is the most frequent liver abnormality observed in overweight or obese children and is strongly associated with metabolic syndrome and insulin resistance. Objectives: (i) To evaluate the effect of a 22-week multidisciplinary intervention program on hepatic fat fraction in overweight or obese children and (ii) to examine the effect of the intervention on cardiometabolic risk factors, self-esteem and well-being. Methods: A total of 160 children, 9-11 years, will be recruited by pediatricians and randomly assigned to control (N = 80) or intervention (N = 80) groups. The control group will receive a family-based lifestyle and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week). The duration of training sessions will be 90 min of exercise, including warm-up, moderate to vigorous aerobic activities, and strength exercises. The primary outcome is the change in hepatic fat fraction (magnetic resonance imaging, MRI). Secondary outcomes include cardiometabolic risk factors such as total adiposity (dual Xray absorptiometry), visceral adiposity (MRI), functional peak aerobic capacity (cardiopulmonary exercise testing), blood pressure, muscular fitness, speed-agility, and fasting blood insulin, glucose, C-reactive protein, alanine aminotransferase, aspartate aminotransferase, gamma glutamyltransferase, lipid profile and psychological measurements (questionnaires). All the measurements will be evaluated at baseline prior to randomization and after the intervention. Discussion: This study will provide insight in the efficacy of a multidisciplinary intervention program including healthy lifestyle education, psycho-education and supervised exercise to reduce hepatic fat and cardiometabolic risk in overweight childrenItem Effectiveness and tolerability of a squalane and dimethicone-based treatment for head lice(2021-04-02) Martínez de Murguía Fernández, Leticia; Puig Algora, Gemma; Bajona Roig, Marta; Bacchini, Gabriela; Tecnalia Research & Innovation; DF_BioeficaciaHead lice (Pediculus humanus capitis) are worldwide obligate human ectoparasites, with high implications in pediatrics. In Europe, first-line topical neurotoxic insecticidal therapeutic strategies are being replaced by topical physically acting agents as the first-choice treatment. Safety of the active ingredients and high efficacy in a one-time single-dose treatment with a brief treatment application time are key issues for consumer use and effective compliance. The aim of this study was to assess the in vitro efficacy of a newly developed squalane and dimethicone-based pediculicidal formula, against motile head lice and eggs after 2 and 5 min immersion in the product, as well as its skin tolerance and acceptability under dermatological and pediatric expert control in children with atopic skin. The results indicate that at both time points, 100% mortality rate of head lice crawling stages and latest age eggs was achieved. The formula was well tolerated and suitable for children with atopic skin from 12 months of age. Showing high in vitro efficacy and good skin acceptability, this solution is presented as a new safe alternative therapy for treatment of head lice infestations.Item Information technologies exposing children to privacy risks: Domains and children-specific technical controls: Domains and children-specific technical controls(2022-08) Crepax, Tommaso; Muntés-Mulero, Victor; Martinez, Jabier; Ruiz, Alejandra; SWT; QuantumEU data protection law requires that digital service providers and system developers put in place technical measures that are adequate to protect children’s informational privacy. The stringent legal obligations of implementing principles of data protection by design into digital systems intensified the engineers’ need to create processes and technological solutions to enhance children’s privacy in digital services. However, in several cases, generic controls have proven to have limited effects on the protection of children’s privacy, raising questions about the need to further develop children- specific technical controls. This paper contributes to address the need for privacy controls by providing (a) a summary of real-world applications of information technologies domains that expose children to privacy risks, and (b) a list that represents the state-of-the-art of the technical controls designed specifically to protect children’s privacy. We identify 24 technical controls that we manually classify with NIST Security and Privacy control categories and Hoepman’s Privacy design strategies. We find that most controls relate to identification and authentication, many of which in the form of techniques for age verification. In general, the vast majority of controls belong to minimization strategies. Our findings show that the field of technical controls specifically designed for children is yet to be developed.Item Prevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trial: Study protocol for a randomized controlled trial(2017-08-10) Arenaza, Lide; Medrano, María; Amasene, María; Rodríguez-Vigil, Beatriz; Díez, Ignacio; Graña, Manuel; Tobalina, Ignacio; Maiz, Edurne; Arteche, Edurne; Larrarte, Eider; Huybrechts, Inge; Davis, Catherine L.; Ruiz, Jonatan R.; Ortega, Francisco B.; Margareto, Javier; Labayen, Idoia; Generales; GenéticaBackground: The global pandemic of obesity has led to an increased risk for prediabetes and type-2 diabetes (T2D). The aims of the current project are: (1) to evaluate the effect of a 22-week family based intervention program, including supervised exercise, on insulin resistance syndrome (IRS) risk in children with a high risk of developing T2D and (2) to identify the profile of microRNA in circulating exosomes and in peripheral blood mononuclear cells in children with a high risk of developing T2D and its response to a multidisciplinary intervention program including exercise. Methods: A total of 84 children, aged 8-12 years, with a high risk of T2D will be included and randomly assigned to control (N = 42) or intervention (N = 42) groups. The control group will receive a family based lifestyle education and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week, 90 min per session including warm-up, moderate to vigorous aerobic activities, and strength exercises). The following measurements will be evaluated at baseline prior to randomization and after the intervention: fasting insulin, glucose and hemoglobin A1c; body composition (dual-energy X-ray absorptiometry); ectopic fat (magnetic resonance imaging); microRNA expression in circulating exosomes and in peripheral blood mononuclear cells (MiSeq; Illumina); cardiorespiratory fitness (cardiopulmonary exercise testing); dietary habits and physical activity (accelerometry). Discussion: Prevention and identification of children with a high risk of developing T2D could help to improve their cardiovascular health and to reduce the comorbidities associated with obesity.