Browsing by Author "Ward, Nick S."
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Item Chronic Stroke Sensorimotor Impairment Is Related to Smaller Hippocampal Volumes: An ENIGMA Analysis: An ENIGMA Analysis(2022-05-17) Zavaliangos‐Petropulu, Artemis; Lo, Bethany; Donnelly, Miranda R.; Schweighofer, Nicolas; Lohse, Keith; Jahanshad, Neda; Barisano, Giuseppe; Banaj, Nerisa; Borich, Michael R.; Boyd, Lara A.; Buetefisch, Cathrin M.; Byblow, Winston D.; Cassidy, Jessica M.; Charalambous, Charalambos C.; Conforto, Adriana B.; DiCarlo, Julie A.; Dula, Adrienne N.; Egorova‐Brumley, Natalia; Etherton, Mark R.; Feng, Wuwei; Fercho, Kelene A.; Geranmayeh, Fatemeh; Hanlon, Colleen A.; Hayward, Kathryn S.; Hordacre, Brenton; Kautz, Steven A.; Khlif, Mohamed Salah; Kim, Hosung; Kuceyeski, Amy; Lin, David J.; Liu, Jingchun; Lotze, Martin; MacIntosh, Bradley J.; Margetis, John L.; Mohamed, Feroze B.; Piras, Fabrizio; Ramos‐Murguialday, Ander; Revill, Kate P.; Roberts, Pamela S.; Robertson, Andrew D.; Schambra, Heidi M.; Seo, Na Jin; Shiroishi, Mark S.; Stinear, Cathy M.; Soekadar, Surjo R.; Spalletta, Gianfranco; Taga, Myriam; Tang, Wai Kwong; Thielman, Gregory T.; Vecchio, Daniela; Ward, Nick S.; Westlye, Lars T.; Werden, Emilio; Winstein, Carolee; Wittenberg, George F.; Wolf, Steven L.; Wong, Kristin A.; Yu, Chunshui; Brodtmann, Amy; Cramer, Steven C.; Thompson, Paul M.; Liew, Sook‐Lei; Zavaliangos-Petropulu, Artemis; Egorova-Brumley, Natalia; Ramos-Murguialday, Ander; Medical TechnologiesBackground. Persistent sensorimotor impairments after stroke can negatively impact quality of life. The hippocampus is vulnerable to poststroke secondary degeneration and is involved in sensorimotor behavior but has not been widely studied within the context of poststroke upper‐limb sensorimotor impairment. We investigated associations between non‐lesioned hippocampal volume and upper limb sensorimotor impairment in people with chronic stroke, hypothesizing that smaller ipsilesional hippocampal volumes would be associated with greater sensorimotor impairment. Methods and Results. Cross‐sectional T1‐weighted magnetic resonance images of the brain were pooled from 357 participants with chronic stroke from 18 research cohorts of the ENIGMA (Enhancing NeuoImaging Genetics through Meta‐Analysis) Stroke Recovery Working Group. Sensorimotor impairment was estimated from the FMA‐UE (Fugl‐Meyer Assessment of Upper Extremity). Robust mixed‐effects linear models were used to test associations between poststroke sensorimotor impairment and hippocampal volumes (ipsilesional and contralesional separately; Bonferroni‐corrected, P<0.025), controlling for age, sex, lesion volume, and lesioned hemisphere. In exploratory analyses, we tested for a sensorimotor impairment and sex interaction and relationships between lesion volume, sensorimotor damage, and hippocampal volume. Greater sensorimotor impairment was significantly associated with ipsilesional (P=0.005; β=0.16) but not contralesional (P=0.96; β=0.003) hippocampal volume, independent of lesion volume and other covariates (P=0.001; β=0.26). Women showed progressively worsening sensorimotor impairment with smaller ipsilesional (P=0.008; β=−0.26) and contralesional (P=0.006; β=−0.27) hippocampal volumes compared with men. Hippocampal volume was associated with lesion size (P<0.001; β=−0.21) and extent of sensorimotor damage (P=0.003; β=−0.15). Conclusions. The present study identifies novel associations between chronic poststroke sensorimotor impairment and ipsilesional hippocampal volume that are not caused by lesion size and may be stronger in women.Item The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain–behavior relationships after stroke: Big data neuroimaging to study brain–behavior relationships after stroke(2020) Liew, Sook‐Lei; Zavaliangos‐Petropulu, Artemis; Jahanshad, Neda; Lang, Catherine E.; Hayward, Kathryn S.; Lohse, Keith R.; Juliano, Julia M.; Assogna, Francesca; Baugh, Lee A.; Bhattacharya, Anup K.; Bigjahan, Bavrina; Borich, Michael R.; Boyd, Lara A.; Brodtmann, Amy; Buetefisch, Cathrin M.; Byblow, Winston D.; Cassidy, Jessica M.; Conforto, Adriana B.; Craddock, R. Cameron; Dimyan, Michael A.; Dula, Adrienne N.; Ermer, Elsa; Etherton, Mark R.; Fercho, Kelene A.; Gregory, Chris M.; Hadidchi, Shahram; Holguin, Jess A.; Hwang, Darryl H.; Jung, Simon; Kautz, Steven A.; Khlif, Mohamed Salah; Khoshab, Nima; Kim, Bokkyu; Kim, Hosung; Kuceyeski, Amy; Lotze, Martin; MacIntosh, Bradley J.; Margetis, John L.; Mohamed, Feroze B.; Piras, Fabrizio; Ramos‐Murguialday, Ander; Richard, Geneviève; Roberts, Pamela; Robertson, Andrew D.; Rondina, Jane M.; Rost, Natalia S.; Sanossian, Nerses; Schweighofer, Nicolas; Seo, Na Jin; Shiroishi, Mark S.; Soekadar, Surjo R.; Spalletta, Gianfranco; Stinear, Cathy M.; Suri, Anisha; Tang, Wai Kwong W.; Thielman, Gregory T.; Vecchio, Daniela; Villringer, Arno; Ward, Nick S.; Werden, Emilio; Westlye, Lars T.; Winstein, Carolee; Wittenberg, George F.; Wong, Kristin A.; Yu, Chunshui; Cramer, Steven C.; Thompson, Paul M.; Zavaliangos-Petropulu, Artemis; Ramos-Murguialday, Ander; Medical TechnologiesThe goal of the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well‐powered meta‐ and mega‐analytic approaches. ENIGMA Stroke Recovery has data from over 2,100 stroke patients collected across 39 research studies and 10 countries around the world, comprising the largest multisite retrospective stroke data collaboration to date. This article outlines the efforts taken by the ENIGMA Stroke Recovery working group to develop neuroinformatics protocols and methods to manage multisite stroke brain magnetic resonance imaging, behavioral and demographics data. Specifically, the processes for scalable data intake and preprocessing, multisite data harmonization, and large‐scale stroke lesion analysis are described, and challenges unique to this type of big data collaboration in stroke research are discussed. Finally, future directions and limitations, as well as recommendations for improved data harmonization through prospective data collection and data management, are provided.