Browsing by Author "Garcia, J."
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Item Assessment of two complementary influenza surveillance systems: Sentinel primary care influenza-like illness versus severe hospitalized laboratory-confirmed influenza using the moving epidemic method(2019-08-13) Torner, Núria; Basile, Luca; Martínez, Ana; Rius, Cristina; Godoy, Pere; Jané, Mireia; Domínguez, Ángela; Aizpurua, J.; Alonso, J.; Azemar, J.; Aizpurua, P.; Ardaya, P. M.; Basas, M. D.; Batalla, J.; Biendicho, P.; Bonet, M.; Callado, M.; Campos, S.; Casanovas, J. M.; Ciurana, E.; Clapes, M.; Cots, J. M.; De La Rica, D.; Domingo, I.; Elizalde, G.; Escapa, P.; Fajardo, S.; Fau, E.; Fernandez, O.; Fernandez, M.; Ferrer, C.; Forcada, A.; Fos, E.; Gadea, G.; Garcia, J.; Garcia, R.; Gatius, C.; Gelado, M. J.; Grau, M.; Grivé, M.; Guzman, M. C.; Hernández, R.; Jimenez, G.; Juscafresa, A.; Llussa, A. M.; López, C.; Kristensen, L.; MacIà, E.; Mainou, A.; Marco, E.; Martínez, M.; Martínez, J. G.; Marulanda, K. V.; Masa, R.; Moncosí, X.; Naranjo, M. A.; Navarro, D.; Ortolà, E.; París, F.; Pérez, M. M.; Pozo, C.; Pujol, R.; Ribatallada, A.; Ruiz, G.; Sabaté, S.; Sanchez, R.; Sarrà, N.; Tarragó, E.; Teixidó, A. M.; Torres, A.; Valén, E.; Van Esso, D.; Van Tarjcwick, C.; Vink Schoenholzer, R.; Zabala, E.; Marcos, M. A.; Mosquera, M. D.M.; De Molina, P.; Rubio, E.; Isanta, R.; Anton, A.; Pumarola, T.; Vilella, A.; Gorrindo, P.; Espejo, E.; Andrés, M.; Barcenilla, F.; Navarro, G.; Barrabeig, I.; Pou, J.; Alvarez, P.; Plasencia, E.; Rebull, J.; Sala, M. R.; Riera, M.; Camps, N.; Follia, N.; Oller, A.; Godoy, P.; Bach, P.; Rius, C.; Hernández, R.; Perez, R.; Torra, R.; Carol, M.; Minguell, S.; Marce, R.; Garcia-Pardo, G.; Olona, M.; Alvarez, A.; Ramon, J. M.; Mòdol, J. M.; Mena, G.; Campins, M.; Massuet, C.; Tora, G.; Ferràs, J.; Ferrús, G.; Tecnalia Research & InnovationBackground: Monitoring seasonal influenza epidemics is the corner stone to epidemiological surveillance of acute respiratory virus infections worldwide. This work aims to compare two sentinel surveillance systems within the Daily Acute Respiratory Infection Information System of Catalonia (PIDIRAC), the primary care ILI and Influenza confirmed samples from primary care (PIDIRAC-ILI and PIDIRAC-FLU) and the severe hospitalized laboratory confirmed influenza system (SHLCI), in regard to how they behave in the forecasting of epidemic onset and severity allowing for healthcare preparedness. Methods: Epidemiological study carried out during seven influenza seasons (2010-2017) in Catalonia, with data from influenza sentinel surveillance of primary care physicians reporting ILI along with laboratory confirmation of influenza from systematic sampling of ILI cases and 12 hospitals that provided data on severe hospitalized cases with laboratory-confirmed influenza (SHLCI-FLU). Epidemic thresholds for ILI and SHLCI-FLU (overall) as well as influenza A (SHLCI-FLUA) and influenza B (SHLCI-FLUB) incidence rates were assessed by the Moving Epidemics Method. Results: Epidemic thresholds for primary care sentinel surveillance influenza-like illness (PIDIRAC-ILI) incidence rates ranged from 83.65 to 503.92 per 100.000 h. Paired incidence rate curves for SHLCI-FLU/PIDIRAC-ILI and SHLCI-FLUA/PIDIRAC-FLUA showed best correlation index' (0.805 and 0.724 respectively). Assessing delay in reaching epidemic level, PIDIRAC-ILI source forecasts an average of 1.6 weeks before the rest of sources paired. Differences are higher when SHLCI cases are paired to PIDIRAC-ILI and PIDIRAC-FLUB although statistical significance was observed only for SHLCI-FLU/PIDIRAC-ILI (p-value Wilcoxon test = 0.039). Conclusions: The combined ILI and confirmed influenza from primary care along with the severe hospitalized laboratory confirmed influenza data from PIDIRAC sentinel surveillance system provides timely and accurate syndromic and virological surveillance of influenza from the community level to hospitalization of severe cases.Item Influenza vaccine effectiveness assessment through sentinel virological data in three post-pandemic seasons(2015-01-01) Torner, Nuria; Martínez, Ana; Basile, Luca; Marcos, M. Angeles; Antón, Andrés; Mosquera, M. Mar; Isanta, Ricard; Cabezas, Carmen; Jané, Mireia; Dominguez, Angela; Aizpurua, P.; Alonso, J.; Azemar, J.; Basas, D.; Besora, R.; Callado, M.; Casanovas, J. M.; Cid, A.; Ciurana, E.; Cots, J. M.; De La Rica, D.; Elizalde Del Rio, G.; Estabanell, A.; Fau, E.; Fernandez, O.; Ferrer, C.; Forcada, A.; Forga, F. X.; Fos, E.; Gadea, G.; Garcia, J.; Garrido, P.; Gatius, C.; Grivé, M.; Guzman, M. C.; Hernandez, R.; Juscafresa, D.; Leon, I.; Macia, E.; Mainou, A.; Marco, E.; Martinez, M.; Martinez, E.; Molinero, C.; Moncosi, X.; Lopez-Mompó, C.; Naranjo, M. A.; Navarro, D.; Ortola, M. E.; Pérez, M. C.; Perez, M. M.; Prat, M.; Pujol, R.; Pujol, J.; Ribatallada, A.; Sánchez, R.; Sarra, N.; Teixidor, A.; Valen, E.; Valencia, I.; Van Esso, D.; Vila, C.; Zabala, E.; Zurilla, E.; Tecnalia Research & InnovationInfluenza vaccination aims at reducing the incidence of serious disease, complications and death among those with the most risk of severe influenza disease. Influenza vaccine effectiveness (VE) through sentinel surveillance data from the PIDIRAC program (Daily Acute Respiratory Infection Surveillance of Catalonia) during 2010-2011, 2011-2012, and 2012-2013 influenza seasons, with three different predominant circulating influenza virus (IV) types [A(H1N1)pdm09, A(H3N2) and B, respectively] was assessed. The total number of sentinel samples with known vaccination background collected during the study period was 3173, 14.7% of which had received the corresponding seasonal influenza vaccine. 1117 samples (35.2%) were positive for IV. A retrospective negative case control design was used to assess vaccine effectiveness (VE) for the entire period and for each epidemic influenza season. An overall VE of 58.1% (95% CI:46.8-67) was obtained. Differences in VE according to epidemic season were observed, being highest for the 2012-2013 season with predominance of IV type B (69.7% ;95% CI:51.5-81) and for the 2010-2011 season, with predominance of the A(H1N1) pdm09 influenza virus strain (67.2% ;95%CI:49.5-78.8) and lowest for the 2011-2012 season with A(H3N2) subtype predominance (34.2% ;95%CI:4.5-54.6). Influenza vaccination prevents a substantial number of influenza-associated illnesses. Although vaccines with increased effectiveness are needed and the search for a universal vaccine that is not subject to genetic modifications might increase VE, nowadays only the efforts to increase vaccination rates of high-risk population and healthcare personnel let reduce the burden of influenza and its complications.Item Multilayer coatings by continuous detonation system spray technique(1998-04-01) Fagoaga, I.; Viviente, J. L.; Gavin, P.; Bronte, J. M.; Garcia, J.; Tagle, J. A.; EXTREMAT; TECNOLOGÍA DE MEMBRANAS E INTENSIFICACIÓN DE PROCESOSSurface protection of high-temperature components for power generation has become one of the most advanced fields of modern engineering. In this area, a multilayer coating of chromium oxide/chromium carbide for erosion-corrosion protection of furnace boiler-walls has been produced by thermal spray continuous detonation system (CDS) technique. These composite coatings present a microstructure made by alternate phases of chromium carbide cermet and oxides resulting from preferential oxidation of chromium compounds. Mechanisms for the generation of such mixed structure are discussed. Produced coatings have been characterized by electron probe microanalysis, X-ray diffraction and ultramicrohardness techniques, combined with traditional procedures of metallographic preparation, quantitative image analysis, and microhardness testing.