TY  - Journal Article
AU  - Lohse, Mirko
AU  - Thesen, Manuel W.
AU  - Haase, Anja
AU  - Smolka, Martin
AU  - Iceta, Nerea Briz
AU  - Ayerdi Izquierdo, Ana
AU  - Ramos, Isbaal
AU  - Salado, Clarisa
AU  - Schleunitz, Arne
TI  - Novel Concept of Micro Patterned Micro Titer Plates Fabricated via UV-NIL for Automated Neuronal Cell Assay Read-Out
PY  - 2021
PB  - Multidisciplinary Digital Publishing Institute (MDPI)
AB  - The UV-nanoimprint lithography(UV-NIL) fabrication of a novel network of micron-sized
channels, forming an open channel microfluidic system is described. Details about the complete
manufacturing process, from mastering to fabrication in small batches and in high throughput with
up to 1200 micro titer plates per hour is presented. Deep insight into the evaluation of a suitable
UV-curable material, mr-UVCur26SF is given, presenting cytotoxic evaluation, cell compatibility
tests and finally a neuronal assay. The results indicate how the given pattern, in combination with
the resist, paves the way to faster, cheaper, and more reliable drug screening.
UR  - http://hdl.handle.net/11556/1108
DX  - 10.3390/nano11040902
ER  -