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dc.contributor.authorRay, Andreas M.
dc.contributor.authorFigueiredo, Thiago D. C.
dc.contributor.authorLópez‐Larraz, Eduardo
dc.contributor.authorBirbaumer, Niels
dc.contributor.authorRamos‐Murguialday, Ander
dc.date.accessioned2020-01-08T15:21:20Z
dc.date.available2020-01-08T15:21:20Z
dc.date.issued2020-04-01
dc.identifier.citationRay, Andreas M., Thiago D. C. Figueiredo, Eduardo López‐Larraz, Niels Birbaumer, and Ander Ramos‐Murguialday. “Brain Oscillatory Activity as a Biomarker of Motor Recovery in Chronic Stroke.” Human Brain Mapping 41, no. 5 (November 28, 2019): 1296–1308. doi:10.1002/hbm.24876.
dc.identifier.issn1065-9471en
dc.identifier.urihttp://hdl.handle.net/11556/836
dc.description.abstractIn the present work, we investigated the relationship of oscillatory sensorimotor brain activity to motor recovery. The neurophysiological data of 30 chronic stroke patients with severe upper‐limb paralysis are the basis of the observational study presented here. These patients underwent an intervention including movement training based on combined brain–machine interfaces and physiotherapy of several weeks recorded in a double‐blinded randomized clinical trial. We analyzed the alpha oscillations over the motor cortex of 22 of these patients employing multilevel linear predictive modeling. We identified a significant correlation between the evolution of the alpha desynchronization during rehabilitative intervention and clinical improvement. Moreover, we observed that the initial alpha desynchronization conditions its modulation during intervention: Patients showing a strong alpha desynchronization at the beginning of the training improved if they increased their alpha desynchronization. Patients showing a small alpha desynchronization at initial training stages improved if they decreased it further on both hemispheres. In all patients, a progressive shift of desynchronization toward the ipsilesional hemisphere correlates significantly with clinical improvement regardless of lesion location. The results indicate that initial alpha desynchronization might be key for stratification of patients undergoing BMI interventions and that its interhemispheric balance plays an important role in motor recovery.en
dc.description.sponsorshipBundesministerium für Bildung und Forschung, Grant/Award Numbers: 13GW0053, 16SV7754; Deutsche Forschungsgemeinschaft; Deutscher Akademischer Austauschdienst, Grant/Award Number: 91563355en
dc.language.isoengen
dc.publisherJohn Wiley and Sons Inc.en
dc.titleBrain oscillatory activity as a biomarker of motor recovery in chronic strokeen
dc.typejournal articleen
dc.identifier.doi10.1002/hbm.24876en
dc.rights.accessRightsopen accessen
dc.subject.keywordsSensorimotor brain activityen
dc.subject.keywordsMotor recoveryen
dc.subject.keywordsSevere upper-limb paralysisen
dc.identifier.essn1097-0193en
dc.issue.number5
dc.journal.titleHuman Brain Mappingen
dc.volume.number41


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