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dc.contributor.authorArenaza, Lide
dc.contributor.authorMedrano, María
dc.contributor.authorAmasene, María
dc.contributor.authorRodríguez-Vigil, Beatriz
dc.contributor.authorDíez, Ignacio
dc.contributor.authorGraña, Manuel
dc.contributor.authorTobalina, Ignacio
dc.contributor.authorMaiz, Edurne
dc.contributor.authorArteche, Edurne
dc.contributor.authorLarrarte, Eider
dc.contributor.authorHuybrechts, Inge
dc.contributor.authorDavis, Catherine L.
dc.contributor.authorRuiz, Jonatan R.
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorMargareto, Javier
dc.contributor.authorLabayen, Idoia
dc.date.accessioned2017-11-13T14:29:19Z
dc.date.available2017-11-13T14:29:19Z
dc.date.issued2017-08-10
dc.identifier.citationArenaza, Lide, María Medrano, María Amasene, Beatriz Rodríguez-Vigil, Ignacio Díez, Manuel Graña, Ignacio Tobalina, et al. “Prevention of Diabetes in Overweight/obese Children through a Family Based Intervention Program Including Supervised Exercise (PREDIKID Project): Study Protocol for a Randomized Controlled Trial.” Trials 18, no. 1 (August 10, 2017). doi:10.1186/s13063-017-2117-y.en
dc.identifier.issn1745-6215en
dc.identifier.urihttp://hdl.handle.net/11556/456
dc.description.abstractBackground: The global pandemic of obesity has led to an increased risk for prediabetes and type-2 diabetes (T2D). The aims of the current project are: (1) to evaluate the effect of a 22-week family based intervention program, including supervised exercise, on insulin resistance syndrome (IRS) risk in children with a high risk of developing T2D and (2) to identify the profile of microRNA in circulating exosomes and in peripheral blood mononuclear cells in children with a high risk of developing T2D and its response to a multidisciplinary intervention program including exercise. Methods: A total of 84 children, aged 8-12 years, with a high risk of T2D will be included and randomly assigned to control (N = 42) or intervention (N = 42) groups. The control group will receive a family based lifestyle education and psycho-educational program (2 days/month), while the intervention group will attend the same lifestyle education and psycho-educational program plus the exercise program (3 days/week, 90 min per session including warm-up, moderate to vigorous aerobic activities, and strength exercises). The following measurements will be evaluated at baseline prior to randomization and after the intervention: fasting insulin, glucose and hemoglobin A1c; body composition (dual-energy X-ray absorptiometry); ectopic fat (magnetic resonance imaging); microRNA expression in circulating exosomes and in peripheral blood mononuclear cells (MiSeq; Illumina); cardiorespiratory fitness (cardiopulmonary exercise testing); dietary habits and physical activity (accelerometry). Discussion: Prevention and identification of children with a high risk of developing T2D could help to improve their cardiovascular health and to reduce the comorbidities associated with obesity.en
dc.description.sponsorshipThe Spanish Ministry of Industry and Competitiveness (DEP2016-78377-R), by “Fondos Estructurales de la Unión Europea (FEDER), Una manera de hacer Europa.” and by the University of the Basque Country (GIU14/21). This work was also supported by grants from Spanish Ministry of Economy and Competitiveness (RYC-2010-05957; RYC- 2011-09011), Spanish Ministry of Education, Culture and Sports (FPU14/ 03329) and by the Education, Linguistic Policy and Culture Department of the Government of the Basque Country (PRE_2016_1_0057).en
dc.language.isoengen
dc.publisherBIOMED CENTRAL LTD, 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLANDen
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titlePrevention of diabetes in overweight/obese children through a family based intervention program including supervised exercise (PREDIKID project): study protocol for a randomized controlled trialen
dc.typearticleen
dc.identifier.doi10.1186/s13063-017-2117-yen
dc.isiYesen
dc.rights.accessRightsopenAccessen
dc.subject.keywordsType-2 diabetesen
dc.subject.keywordsChildrenen
dc.subject.keywordsExerciseen
dc.subject.keywordsFamily based lifestyle intervention programen
dc.subject.keywordsmiRNAen
dc.subject.keywordsEctopic faten
dc.issue.number1en
dc.journal.titleTrialsen
dc.volume.number18en


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