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dc.contributor.authorHautasaari, Pekka
dc.contributor.authorSavić, Andrej M.
dc.contributor.authorLoberg, Otto
dc.contributor.authorNiskanen, Eini
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorKujala, Urho M.
dc.contributor.authorTarkka, Ina M.
dc.date.accessioned2017-03-07T14:35:50Z
dc.date.available2017-03-07T14:35:50Z
dc.date.issued2017-01
dc.identifier.citationHautasaari Pekka, Savić Andrej M.,Loberg Otto, Niskanen Eini, Kaprio Jaakko, Kujala Urho M., Tarkka Ina M., Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History: Evidence from Monozygotic Twins, Brain Topography, 2017, Vol 30, no.1, 77-86. 10.1007/s10548-016-0531-1en
dc.identifier.issn0896-0267en
dc.identifier.urihttp://hdl.handle.net/11556/372
dc.description.abstractAssociations between long-term physical activity and cortical function and brain structure are poorly known. Our aim was to assess whether brain functional and/or structural modulation associated with long-term physical activity is detectable using a discordant monozygotic male twin pair design. Nine monozygotic male twin pairs were carefully selected for an intrapair difference in their leisure-time physical activity of at least three years duration (mean age 34 ± 1 years). We registered somatosensory mismatch response (SMMR) in EEG to electrical stimulation of fingers and whole brain MR images. We obtained exercise history and measured physical fitness and body composition. Equivalent electrical dipole sources of SMMR as well as gray matter (GM) voxel counts in regions of interest indicated by source analysis were evaluated. SMMR dipolar source strengths differed between active and inactive twins within twin pairs in postcentral gyrus, medial frontal gyrus and superior temporal gyrus and in anterior cingulate (AC) GM voxel counts differed similarly. Compared to active twins, their inactive twin brothers showed greater dipole strengths in short periods of the deviant-elicited SMMR and larger AC GM voxel counts. Stronger activation in early unattended cortical processing of the deviant sensory signals in inactive co-twins may imply less effective gating of somatosensory information in inactive twins compared to their active brothers. Present findings indicate that already in 30′s long-term physical activity pattern is linked with specific brain indices, both in functional and structural domains.en
dc.description.sponsorshipAuthors wish to thank the participants of the study and laboratory personnel and students at the University of Jyva¨skyla¨ who contributed to this study. Support from the Juho Vainio Foundation (Helsinki) is acknowledged (to I M Tarkka). Data collection in the twin cohort has been supported by National Institute of Alcohol Abuse and Alcoholism (Grants AA-12502, AA-00145, and AA-09203 to R J Rose) and the Academy of Finland (Grants 100499, 265240, 263278 and 264146 to J Kaprio).en
dc.language.isoengen
dc.publisherSPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDSen
dc.titleSomatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History: Evidence from Monozygotic Twinsen
dc.typearticleen
dc.identifier.doi10.1007/s10548-016-0531-1en
dc.isiYesen
dc.rights.accessRightsembargoedAccessen
dc.subject.keywordsTwin researchen
dc.subject.keywordsBrain electrophysiologyen
dc.subject.keywordsSomatosensory cortexen
dc.subject.keywordsMismatch negativityen
dc.subject.keywordsBrain structureen
dc.subject.keywordsPhysical activityen
dc.identifier.essn1573-6792en
dc.issue.number1en
dc.journal.titleBrain Topographyen
dc.page.final86en
dc.page.initial77en
dc.volume.number30en


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