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dc.contributor.authorBraceras, I.
dc.contributor.authorAlava, J.I.
dc.contributor.authorGoikoetxea, L.
dc.contributor.authorde Maeztu, M.A.
dc.contributor.authorOnate, J.I.
dc.date.accessioned2015-06-10T12:21:33Z
dc.date.available2015-06-10T12:21:33Z
dc.date.issued2007-08-05
dc.identifier.citationSurface and Coatings Technology, Volume 201, Issues 19–20, 5 August 2007, Pages 8091-8098en
dc.identifier.issn0257-8972en
dc.identifier.urihttp://hdl.handle.net/11556/22
dc.description.abstractThe reaction of living tissues to foreign materials is a highly complex process that currently is insufficiently understood. Nevertheless, if specific reactions are to be promoted, this understanding is highly valuable and thus a significant research effort is being devoted to this issue. Typically, when a biomaterial is inserted in living tissue, proteins and other bio-molecules will adsorb to the surface. As this protein layer will mediate the interaction of the biomaterial with the living world, the consequent reactions will be highly dependant on this very first stage. Furthermore, different materials, i.e. surfaces, typically elicit a very different tissue response. It is commonly admitted that the primary adsorption depends heavily on the surface chemistry, surface topography and surface physical characteristics. Interactions between surface micro-topography and living cells have been widely studied, but protein specific reactions versus nano-topography have been barely explored. Ion beam modification of surfaces, which affect these key properties, can therefore be (i) a powerful tool to advance in the understanding of these nanoscale phenomena and (ii) useful as an industrial treatment of high value added medical devices. This work will explore the application of ion beam based surface treatments to cause specific reactions in hard tissue regeneration. A variety of in vitro and in vivo results are presented corresponding to ion implantation treatments promoting '' osseointegration '' or intimate binding between the biomaterial and the living tissue, without any soft tissue interlayer, and an overview of the mechanism behind is offered, i.e. among other behaviour of osteoblasts, signalling proteins as the integrins, nanotopographic parameters.en
dc.description.sponsorshipBasque Government, Department of Industry, project ref. IC-2004/0027900.en
dc.language.isoengen
dc.publisherELSEVIER SCIENCE SA, PO BOX 564, 1001 LAUSANNE, SWITZERLANDen
dc.titleInteraction of engineered surfaces with the living world: Ion implantation vs. osseointegrationen
dc.typearticleen
dc.identifier.doi10.1016/j.sur-fcoat.2006.03.052en
dc.isiYesen
dc.rights.accessRightsembargoedAccessen
dc.subject.keywordsion implantationen
dc.subject.keywordsosseointegrationen
dc.subject.keywordsdental implantsen
dc.subject.keywordsapoptosisen


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