dc.contributor.author | Cicuéndez, Mónica | |
dc.contributor.author | Casarrubios, Laura | |
dc.contributor.author | Feito, María José | |
dc.contributor.author | Madarieta, Iratxe | |
dc.contributor.author | Garcia-Urkia, Nerea | |
dc.contributor.author | Murua, Olatz | |
dc.contributor.author | Olalde, Beatriz | |
dc.contributor.author | Briz, Nerea | |
dc.contributor.author | Diez-Orejas, Rosalía | |
dc.contributor.author | Portolés, María Teresa | |
dc.date.accessioned | 2021-06-16T07:48:04Z | |
dc.date.available | 2021-06-16T07:48:04Z | |
dc.date.issued | 2021-05-17 | |
dc.identifier.citation | Cicuéndez, Mónica, Laura Casarrubios, María José Feito, Iratxe Madarieta, Nerea Garcia-Urkia, Olatz Murua, Beatriz Olalde, Nerea Briz, Rosalía Diez-Orejas, and María Teresa Portolés. “Candida albicans/Macrophage Biointerface on Human and Porcine Decellularized Adipose Matrices.” Journal of Fungi 7, no. 5 (May 17, 2021): 392. doi:10.3390/jof7050392. | en |
dc.identifier.uri | http://hdl.handle.net/11556/1148 | |
dc.description.abstract | Macrophages, cells effective in sensing, internalizing and killing Candida albicans, are intertwined
with the extracellular matrix (ECM) through different signals, which include the release of specific
cytokines. Due to the importance of these interactions, the employment of in vitro models mimicking
a fungal infection scenario is essential to evaluate the ECM effects on the macrophage response.
In this work, we have analyzed the effects of human and porcine decellularized adipose matrices
(DAMs), obtained by either enzymatic or organic solvent treatment, on the macrophage/Candida albicans
interface. The present study has allowed us to detect differences on the activation of macrophages
cultured on either human- or porcine-derived DAMs, evidencing changes in the macrophage actin
cytoskeleton, such as distinct F-actin-rich membrane structures to surround the pathogen. The
macrophage morphological changes observed on these four DAMs are key to understand the defense
capability of these cells against this fungal pathogen. This work has contributed to the knowledge of
the influence that the extracellular matrix and its components can exert on macrophage metabolism,
immunocompetence and capacity to respond to the microenvironment in a possible infection scenario. | en |
dc.description.sponsorship | This work has been supported by the European Union’s Horizon 2020 Research and Innovation Programme (H2020-FETOPEN-2018-2020, NeuroStimSpinal Project, Grant AgreementNo. 829060). M.C. acknowledges the European Union0s Horizon 2020 Research and InnovationProgramme for her contract under the NeuroStimSpinal Project. LC is grateful to the Universidad Complutense de Madrid for a UCM fellowship | en |
dc.language.iso | eng | en |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | en |
dc.rights | Attribution 4.0 International | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Candida albicans/Macrophage Biointerface on Human and Porcine Decellularized Adipose Matrices | en |
dc.type | journal article | en |
dc.identifier.doi | 10.3390/jof7050392 | en |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/829060/EU/A STEP FORWARD TO SPINAL CORD INJURY REPAIR USING INNOVATIVE STIMULATED NANOENGINEERED SCAFFOLDS/NeuroStimSpinal | en |
dc.rights.accessRights | open access | en |
dc.subject.keywords | Candida albicans | en |
dc.subject.keywords | Macrophage | en |
dc.subject.keywords | Extracellular matrix | en |
dc.subject.keywords | Decellularization | en |
dc.subject.keywords | Immunocompetence | en |
dc.subject.keywords | Phagocytosis | en |
dc.identifier.essn | 2309-608X | en |
dc.issue.number | 5 | en |
dc.journal.title | Journal of Fungi | en |
dc.page.initial | 392 | en |
dc.volume.number | 7 | en |