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dc.contributor.authorCicuéndez, Mónica
dc.contributor.authorCasarrubios, Laura
dc.contributor.authorFeito, María José
dc.contributor.authorMadarieta, Iratxe
dc.contributor.authorGarcia-Urkia, Nerea
dc.contributor.authorMurua, Olatz
dc.contributor.authorOlalde, Beatriz
dc.contributor.authorBriz, Nerea
dc.contributor.authorDiez-Orejas, Rosalía
dc.contributor.authorPortolés, María Teresa
dc.date.accessioned2021-06-16T07:48:04Z
dc.date.available2021-06-16T07:48:04Z
dc.date.issued2021-05-17
dc.identifier.citationCicuéndez, Mónica, Laura Casarrubios, María José Feito, Iratxe Madarieta, Nerea Garcia-Urkia, Olatz Murua, Beatriz Olalde, Nerea Briz, Rosalía Diez-Orejas, and María Teresa Portolés. “Candida albicans/Macrophage Biointerface on Human and Porcine Decellularized Adipose Matrices.” Journal of Fungi 7, no. 5 (May 17, 2021): 392. doi:10.3390/jof7050392.en
dc.identifier.urihttp://hdl.handle.net/11556/1148
dc.description.abstractMacrophages, cells effective in sensing, internalizing and killing Candida albicans, are intertwined with the extracellular matrix (ECM) through different signals, which include the release of specific cytokines. Due to the importance of these interactions, the employment of in vitro models mimicking a fungal infection scenario is essential to evaluate the ECM effects on the macrophage response. In this work, we have analyzed the effects of human and porcine decellularized adipose matrices (DAMs), obtained by either enzymatic or organic solvent treatment, on the macrophage/Candida albicans interface. The present study has allowed us to detect differences on the activation of macrophages cultured on either human- or porcine-derived DAMs, evidencing changes in the macrophage actin cytoskeleton, such as distinct F-actin-rich membrane structures to surround the pathogen. The macrophage morphological changes observed on these four DAMs are key to understand the defense capability of these cells against this fungal pathogen. This work has contributed to the knowledge of the influence that the extracellular matrix and its components can exert on macrophage metabolism, immunocompetence and capacity to respond to the microenvironment in a possible infection scenario.en
dc.description.sponsorshipThis work has been supported by the European Union’s Horizon 2020 Research and Innovation Programme (H2020-FETOPEN-2018-2020, NeuroStimSpinal Project, Grant AgreementNo. 829060). M.C. acknowledges the European Union0s Horizon 2020 Research and InnovationProgramme for her contract under the NeuroStimSpinal Project. LC is grateful to the Universidad Complutense de Madrid for a UCM fellowshipen
dc.language.isoengen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleCandida albicans/Macrophage Biointerface on Human and Porcine Decellularized Adipose Matricesen
dc.typearticleen
dc.identifier.doi10.3390/jof7050392en
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/829060/EU/A STEP FORWARD TO SPINAL CORD INJURY REPAIR USING INNOVATIVE STIMULATED NANOENGINEERED SCAFFOLDS/NeuroStimSpinalen
dc.rights.accessRightsopenAccessen
dc.subject.keywordsCandida albicansen
dc.subject.keywordsMacrophageen
dc.subject.keywordsExtracellular matrixen
dc.subject.keywordsDecellularizationen
dc.subject.keywordsImmunocompetenceen
dc.subject.keywordsPhagocytosisen
dc.identifier.essn2309-608Xen
dc.issue.number5en
dc.journal.titleJournal of Fungien
dc.page.initial392en
dc.volume.number7en


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    Attribution 4.0 InternationalExcept where otherwise noted, this item's license is described as Attribution 4.0 International