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dc.contributor.authorMartínez de Murguía Fernández, Leticia
dc.contributor.authorPuig Algora, Gemma
dc.contributor.authorBajona Roig, Marta
dc.contributor.authorBacchini, Gabriela
dc.date.accessioned2021-05-12T08:49:53Z
dc.date.available2021-05-12T08:49:53Z
dc.date.issued2021-04-02
dc.identifier.citationMartínez de Murguía Fernández, Leticia, Gemma Puig Algora, Marta Bajona Roig, and Gabriela Bacchini. “Effectiveness and Tolerability of a Squalane and Dimethicone-Based Treatment for Head Lice.” Parasitology Research (April 2, 2021). doi:10.1007/s00436-021-07113-y.en
dc.identifier.issn0932-0113en
dc.identifier.urihttp://hdl.handle.net/11556/1133
dc.description.abstractHead lice (Pediculus humanus capitis) are worldwide obligate human ectoparasites, with high implications in pediatrics. In Europe, first-line topical neurotoxic insecticidal therapeutic strategies are being replaced by topical physically acting agents as the first-choice treatment. Safety of the active ingredients and high efficacy in a one-time single-dose treatment with a brief treatment application time are key issues for consumer use and effective compliance. The aim of this study was to assess the in vitro efficacy of a newly developed squalane and dimethicone-based pediculicidal formula, against motile head lice and eggs after 2 and 5 min immersion in the product, as well as its skin tolerance and acceptability under dermatological and pediatric expert control in children with atopic skin. The results indicate that at both time points, 100% mortality rate of head lice crawling stages and latest age eggs was achieved. The formula was well tolerated and suitable for children with atopic skin from 12 months of age. Showing high in vitro efficacy and good skin acceptability, this solution is presented as a new safe alternative therapy for treatment of head lice infestations.en
dc.description.sponsorshipThis work was funded by Ferrer International S.A., the company that developed the human head louse treatment discussed in this paper. This solution is marketed as “OTC ANTIPIOJOS FORMULA TOTAL” by Ferrer International S.A. in Spain.en
dc.language.isoengen
dc.publisherSpringeren
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleEffectiveness and tolerability of a squalane and dimethicone-based treatment for head liceen
dc.typearticleen
dc.identifier.doi10.1007/s00436-021-07113-yen
dc.rights.accessRightsopenAccessen
dc.subject.keywordsHead liceen
dc.subject.keywordsPediculicidesen
dc.subject.keywordsPhysically actingen
dc.subject.keywordsOvicidalen
dc.subject.keywordsIn vitro efficacyen
dc.subject.keywordsChildrenen
dc.identifier.essn1432-1955en
dc.issue.number5en
dc.journal.titleParasitology Researchen
dc.page.final1890en
dc.page.initial1883en
dc.volume.number120en


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    Attribution 4.0 InternationalExcept where otherwise noted, this item's license is described as Attribution 4.0 International