Show simple item record

Novel Concept of Micro Patterned Micro Titer Plates Fabricated via UV-NIL for Automated Neuronal Cell Assay Read-Out

dc.contributor.authorLohse, Mirko
dc.contributor.authorThesen, Manuel W.
dc.contributor.authorHaase, Anja
dc.contributor.authorSmolka, Martin
dc.contributor.authorIceta, Nerea Briz
dc.contributor.authorAyerdi Izquierdo, Ana
dc.contributor.authorRamos, Isbaal
dc.contributor.authorSalado, Clarisa
dc.contributor.authorSchleunitz, Arne
dc.date.accessioned2021-04-13T10:43:14Z
dc.date.available2021-04-13T10:43:14Z
dc.date.issued2021-04-01
dc.identifier.citationLohse, Mirko, Manuel W. Thesen, Anja Haase, Martin Smolka, Nerea Briz Iceta, Ana Ayerdi Izquierdo, Isbaal Ramos, Clarisa Salado, and Arne Schleunitz. “Novel Concept of Micro Patterned Micro Titer Plates Fabricated via UV-NIL for Automated Neuronal Cell Assay Read-Out.” Nanomaterials 11, no. 4 (April 1, 2021): 902. doi:10.3390/nano11040902.en
dc.identifier.urihttp://hdl.handle.net/11556/1108
dc.description.abstractThe UV-nanoimprint lithography(UV-NIL) fabrication of a novel network of micron-sized channels, forming an open channel microfluidic system is described. Details about the complete manufacturing process, from mastering to fabrication in small batches and in high throughput with up to 1200 micro titer plates per hour is presented. Deep insight into the evaluation of a suitable UV-curable material, mr-UVCur26SF is given, presenting cytotoxic evaluation, cell compatibility tests and finally a neuronal assay. The results indicate how the given pattern, in combination with the resist, paves the way to faster, cheaper, and more reliable drug screening.en
dc.description.sponsorshipThis project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement NO. 646260. The research was also partially supported by NextGenMicrofluidics project under HORIZON2020 with grant agreement no 862092.en
dc.language.isoengen
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en
dc.rightsAttribution 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleNovel Concept of Micro Patterned Micro Titer Plates Fabricated via UV-NIL for Automated Neuronal Cell Assay Read-Outen
dc.typearticleen
dc.identifier.doi10.3390/nano11040902en
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/646260/EU/Large scale micro-and nanofabrication technologies for bioanalytical devices based on R2R imprinting/R2R Biofluidicsen
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/862092/EU/Next generation test bed for upscaling of microfluidic devices based on nano-enabled surfaces and membranes/NextGenMicrofluidicsen
dc.rights.accessRightsopenAccessen
dc.subject.keywordsNanoimprint lithographyen
dc.subject.keywordsR2R UV-NILen
dc.subject.keywordsNeuronal cell assayen
dc.identifier.essn2079-4991en
dc.issue.number4en
dc.journal.titleNanomaterialsen
dc.page.initial902en
dc.volume.number11en


Files in this item

Thumbnail
Name:
nanomaterials-11-00902.pdf
Size:
1.141Mb
Format:
PDF
View/Open

    Show simple item record

    Attribution 4.0 InternationalExcept where otherwise noted, this item's license is described as Attribution 4.0 International